ARose, thank you for the thorough and informative update. Glad your wife is doing better. With the MTHFR, it was discovered via genetic testing. It was specific to just the MTHFR, I have not had my entire genome tested. As to the mast cell activation, I highly recommend a book by Dr. Lawrence Afrin, "Never Bet Against Occam." Just before the COVID pandemic, I had received a referral to a doctor in our area who specializes in mast cell activation syndromes/disorders. No chance to follow up with that. I am currently doing very well. Your wife's experience with left leg issues sounds similar to what happened to me three months out from finishing the series. Sudden left leg pain and tightness and what I can only describe as a partial paralysis sensation from the left pelvis on down. I just could not move properly and without great pain. Completely resolved.