I haven't tried either of these drugs but Tecfidera is less likely to cause liver damage according to these studies:
Plegridy is one of the interferons, and so this information applies to it--from a study done at the National Institute of Diabetes and Digestive and Kidney Diseases a couple of years back:
Beta Interferon - LiverTox - NCBI Bookshelf
The same overview found that Tecfidera has involved less liver damage--specifically:
Quote:
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Likelihood score: C (probable rare cause of clinically apparent liver injury).
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Dimethyl Fumarate - LiverTox - NCBI Bookshelf
However, there have been a few PML cases in patients taking Tecfidera. I'm sorry I don't have any information on Plegridy and PML.
You might want to weigh the risks of one drug against the risks of the other.