I've used desipramine for the first 2 years of my idiopathic SFN and it relieved tingling and what I called "sunburns". It worked for me and I continue to take it at the dosage of 60mg per day and have taken it for 5.5 years. At 3 years into my SFN I started Gabapentin which has provided better relief from sharp, shooting pains. Gabapentin dose is 60mg per day. Hope this helps