Hi and thanks for all who replied, I should I guess be ok with the ones I have at 100mg a day, i just did not want to under dose and not get the full effectiveness of the supplement and stop using them down the road thinking it is not working for me. I guess its hit and miss as everyone is different. Experimental some what, up the dose down the dose till you either feel some relief from it or not. How about the acetyl-l-carnitine and the befotiamine for SFN, has anyone had any good progress by using these two with R alfa lipoic acid?