It sounds as if something more acute is going on right now. Just as an example, I have a GBS style neuropathy from a confused immune system. But I have PN in both hands and feet. One day I had to post because my hands felt like they were on fire. They also swelled up and looked like big gorrilla hands, and were very sore,inflamed and raw feeling. At first I thought it may have been PN behaving oddly. But I had the same thing happen to my ears and my elbows. It was some sort of acute allergic reaction to a cleaner I used at home. It lasted a good 2 weeks,and after it finally went away it felt like their was more damage to my hands for a while.

Are you sure your new meds couldn't be causing you problems? Have you taken or eaten anything out of the ordinary? Fatigue also suggests something possibly acute like an infection or an allergic reaction.