Originally Posted by twitchy_bar

I'm joining the party here. Recently developed suspected SFN and am very interested in these antimuscarinics. At this point, they seem like the best option for fending off progression while the very slow FDA research does its thing on the existing avenues for PN drugs.

I'm waiting on a box Pirenzepine pills from Japan, with plans to attempt compounding myself. There is a user on Reddit who seemed to have a decent formula, and mncyclist in this thread might also be onto something.

There was also an account on Reddit of someone who had success using it orally, though Winsantor has said it's inadvisable due to the dosage you'd need. I read somewhere you will only absorb 25% of the medication when taken orally.

There is also information about the use of PDE5-inhibitors (Viagra, Cialis) in the treatment of PN. Though I haven't tried this myself yet.

I'm not recommending anything in this post, just reporting on what I've read.

We're a small community– those who have PN who are willing to self-experiment (within reason) and help ourselves where our doctors cannot. So I will commit to updating this thread after trying any of these interventions.

Any new info on compounding techniques and/or results would be greatly appreciated.