I have been using DMSO for the past 3 months with great success. I use the clear liquid in a spray bottle I find that to be the easiest. My neuropathy is in my toe area so I put a towel on the floor to catch the over spray then spray the top and bottom of the front of my feet. I find that it last a lot longer than the cannabis cbd that I was using(that was only 3 1/2hrs at best). It also works great on arthritis which I also suffer from.