I got my first one almost 3 weeks ago, holding my immunosuppresants and SQIG... did have some exacerbation after it (droopy face, snarl of a smile, and generalized weakness with some swallowing issues).. but tolerable.. and got much better once i got back on my immunosuppresant and SQIG... I have shot number two this week.. and I am nervous for that one! But with the new data coming in about the effectiveness with the delta variant, I'll be happy to hopefully have some immunity, esp with the littles headed back to school in August