These journal papers give thorough Amyotrophic Lateral Sclerosis syndrome introduction and show the achievements of medical science over the recent last centuries. Several are easy reads. The one from Doctors Brown and Al-Chalabi is likely the most difficult as it articulates the frontier of genetics found bearing on the discovered disease processes.

Unexpected decline in survival from amyotrophic lateral sclerosis/motor neurone disease
Unexpected decline in survival from amyotrophic lateral sclerosis/motor neurone disease | Journal of Neurology, Neurosurgery & Psychiatry

Bunina bodies
http://www.grandroundsjournal.com/ar...2/gr10l002.pdf

Young-onset amyotrophic lateral sclerosis: historical and other observations
Young-onset amyotrophic lateral sclerosis: historical and other observations | Brain | Oxford Academic

Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis - PubMed

Amyotrophic Lateral Sclerosis: Disease State Overview
Amyotrophic lateral sclerosis: disease state overview - PubMed

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
https://pubmed.ncbi.nlm.nih.gov/21832997/

Identification of unexpected respiratory abnormalities in patients with amyotrophic lateral sclerosis through electromyographic analysis using intramuscular electrodes implanted for therapeutic diaphragmatic pacing
https://pubmed.ncbi.nlm.nih.gov/25648901/

The last paper shows diaphragmatic electromyogram reflecting potential biomarker value . . . a major goal of current medical research. :candle smiley: