I'm now in my 26th year with PD. Onset of symptoms was 1996 at age 33. Things are not good, as I'm sure you can imagine. I'm supposed to take 3 Sinemet (25/100mg) four times/day. This dose used to last 5-6 hrs., which worked out well enough for several years. These days, however, I start to wear-off in about 3 hrs. So, now I'm faced with deciding whether or not to go ahead and take "more" than I am prescribed. You see, a VA doc writes my prescriptions, and he recently sent me a large "extra" bottle of Sinemet (Qty: 180). I'm assuming he sent them because I told him about the 2-3 hrs of On-time I regularly get from the 3-tab dose.
Obviously, the longer we take the sinemet, the less effective it becomes. So, I was wondering if anyone here has past the point I find myself in currently? Anyone here taking more than 3 tabs (25/100mg) four times daily?
...and, what am I (are We) supposed to do if/when the sinemet fails completely?
Thanks very much.