Well, OP, could the melatonin be your problem? Sounds like you've tried so much and as for the meds, I would not take them and never have...All supplements and Inosine and Sphingolin do a good job, they did for me.

How much Melatonin do you take, I keep my dose at 1/2mg and it's in my Sleep Combo which I have posted in the Sleep Forum
here.

I ended up with neuropathy from a hip replacement and the tingle burn is pretty much gone, but the damage
from the surgery lives with me. I've taken Grape Seed Extract for decades and could be too it helps with the
neuropathy issues...it's a powerful antioxidant. Let us know how you are doing...