I am so sorry for your loss. I also am surprised we have nothing better than levodopa after all of this time and money. It is very discouraging, but there are some things that I think provide those of us in the PD community with hope:

1. I am following the autologous stem cell researchers and hope that this can be a treatment for PWP soon.

2. I was optimistic to read about Inflazome's acquisition by Roche for almost half a billion dollars in late 2020, but it just disappeared off the radar once the acquisition was made. Inflazome's research sounded quite promising, dealing with inflammation, and two of their drug candidates had already completed Phase 1 safety. You can read more about this here:

https://cen.acs.org/business/mergers...million/98/i37

Wishing you all a safe and healthy 2023