--so I'm not sure, with limited connectivity, when she would jump in, but both she and Rose have talked about people who have trouble metabolizing B6--generally due to an enzymatic deficiency--using the P-5-P form of B6, which is coenzymated and much easier to process for such people, who otherwise can have a "build-up" of non-metabolized B6 that their bodies are not processing/eliminating.

It's likely that a number of the reports of B6 toxicity in the literature--at least among people who aren't taking grams of it each day--involved people who did have such enzymatic deficiency and built up toxic levels over time.