Dear Mama,

To my knowledge, (If I only had a brain,) the only proven oversensitivity to Sinemet is someone with a genetic component. Those with the genetic mutations are far more likely to be affected by the slightest change in their Sinemet dose. DBS surgery can be a life saving measure but people with the gene mutations are more difficult to program.

The only problem with having DBS too early, is once you have it, you can no longer participate in many research studies and you can have no MRI's for any reason. Don't be in too big a hurry to have DBS as you will reduce your options for participating in research or needing an MRI to diagnose something unrelated to your Parkinson's disease.

Vicky