...as I am a recently dx diabetic and my neuropathy mysteriously coincided with the start of my meds. The meds ( Glucovance ) lowered my lipids, cholesterol, and glucose to "remarkable" levels ( doctors words ). I swear , I believe the damn stuff causes a major metabolisim shift and depletes a lot of good stuff too! Proof..I don't have, but common sense says yes. Anyway, I going to start gulping some b-1---thnx Tony!