Just saw my pain dr. at U.S.C. this morning for another Zometa infusion. He tells me that there's every reason to believe that Zometa and other bisphosphonates work directly on the nerves, where not every RSD patient experiences a loss in bone density: I certainly did not.

He also tells me that based upon what he understands through the literature and speaking with colleagues, although his personal experience in treating this patient population with Zometa is somewhat limited, that these drugs should work for burning RSD skin pain and touch sensitivity.

In any event, this is something that those of us fortunate enough to not need major dental work in the near term should be discussing with our doctors. (And to the extent everyone else can get their dental work done before trying the stuff, so much the better.)

Mike