Karen, when i had the shots of hydroxo, i don't notice anything as far as symptoms go, i have been very fortunate to have healed most of my nerve damage, healing was a rough and bumpy road over all, i only have a very slight burn every now and again, which a lot of my success is due to Rose's great advise about b12.
I would confidently say that B12 Cynno daily and b12 Hydroxo shots occasionaly
has played a major part in repairing the nerves both my large and small fibres, and of course correcting my prediabetic state as well with diet has to be included.