How is it that there are people who "survive" the most debilitating symptoms of PD for many years, before they finally start complaining about things that have "hit" the rest of us like a ton of bricks early after dx?
It must have something to do with the norepinephrine "pump". When i take Ritalin, on a good day, i can actually do things and go places that i simply cannot on bad days. Thus a "stimulatory" component that is missing, i feel generally is part and parcel to the manifestations of PD symptoms. However, focusing in on the cholinergic system is not the whole story either, while anticholinergics generally help with PD symptoms, we have not seen the wide use of amphetamine like norepinephrine mimetics to help combat PD symptomology.