I was hoping isradipine would work for me, but it didn't. I have high blood pressure so my doctor agreed to let me try isradipine in place of my other bp medication, although he wasn't very hopeful. He had prescribed it to other patients without much luck. He gave me a prescription for 10mg. once a day, and made an appointment to see me the following week. It didn't take more than a few days for me to see the edema in my feet and ankles increase, even though I was already taking another med that contained a diuretic. At my next appointment we both agreed isradipine was not for me. I hope others can tolerate it, especially if it proves to be helpful to PWP.