http://www.merck.com/mmpe/sec01/ch004/ch004h.html

Also check out this portion of the boards:
http://neurotalk.psychcentral.com/forumdisplay.php?f=49

B-1 and B-12 are like Vitamin C, in that you can exceed maximum dosages and hot hurt yourself in the process- what is not used passes on out. B-6, tho Stays in the body, and if you take in far more than you need, it builds up and starts to cause problems.

In my own situation, after trying to be ever so careful..to put as much 'good stuff' into myself to 'help' the healing, I found that B-6 in particular was an [unnecessary] additive in many other important supplements. Soo, I started out by eliminating most of my supplements and adding new ones very carefully to keep my b-6 at a medium recommended daily dose. My neuropathy improved some with this change, but, on the better side, it wasn't getting worse. Some of us are well, more sensitive/tolerant/intolerant to some medications, supplements and therapies than others.

Further we all seem to have come down the 'neuropathy pathway' from many different directions. So much about our onsets, diagnoses, treatments and outcomes varies - as varied - as we, as people are!

Sometimes it's like asking a ouija board about it all...between the docs [diagnosing or not], medications [working or not] and everything else in-between! I hope this helps you learn and find your own good way to feeling better - j