--although I couldn't find the specific thread this morning--darn.

The bottom line is that yes, there have been documented cases of Vitamin B6toxicity in the literature--usually the effect is a parasthetic sensory neuropathy that recedes once the megadosing is cut down.

Most of the cases reported have been at very high dosae levels--in excess of 200mg/day. Most of us here try to remain safe by not going above 50mg, or at most 100mg, daily.

It is also possible that people who experienced this have an enzymatic deficiency in the way they process pyridoxine, the usaul from in which B6 supplements are found, which allows B6 levels to build. From what I've researched, toxicity does not seem to be a problem with those who take their B6 in the co-enzymated P-5-P form, which they can process and eliminate (which is now available from many on-line supplement merchants).

(I'm sure when Mrs. D get back from the island she'll notice this and talk about it in more detail than I can.)