Well , my neuropathy is ok most days thanks to Lyrica. Of course it is most noticeable at night. During the day I notice it a little in my face and ankle area. It does not seem to center around the weather or any environmental state. I actually had neuropathy in March shortly after starting my Glucovance, and oddly enough , it disappeared after four days. In mid April , I started my dinner time dose and shortly thereafter ,the Neuropathy came back with a vengance and apparently has decided to stay. I am taking my Methyl b ( 1.5 mg ) every day plus Alpha Linoec Acid and L Acetyl Carnintine.I started the Methyl because I had malaise and fatigue and had a pretty low level (530). I have seen a lot of studies that subscribe to the fact that 500 is the low mark for healthy levels and I believe it!...Tom