Hi fee,
My son had similar experience with Risperdal/Risperidone when he was young. I've heard about this from time to time. It's as if the medication hits a wall and stops being helpful or effective.
Earlier this year I read and saved an article written about similar outcome with antispychotic medications. Not that this is of any real help to you, but it is interesting.
http://www.jneurosci.org/cgi/content...act/27/11/2979
Behavioral/Systems/Cognitive
"Breakthrough" Dopamine Supersensitivity during Ongoing Antipsychotic Treatment Leads to Treatment Failure over Time
Anne-Noël Samaha, Philip Seeman, Jane Stewart, Heshmat Rajabi, and Shitij Kapur
Quote:
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Thus, the loss of antipsychotic efficacy is linked to an increase in D2 receptor number and sensitivity. These results are the first to demonstrate that "breakthrough" supersensitivity during ongoing antipsychotic treatment undermines treatment efficacy. These findings provide a model and a mechanism for antipsychotic treatment failure and suggest new directions for the development of more effective antipsychotics.
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