hi zucchini, the entirety of my knowledge of Lingo-1 (in addition to the first post)--appears important in neuronal plasticity

Neuronal activity-induced regulation of Lingo-1.

REGENERATION AND TRANSPLANTATION

Neuroreport. 15(15):2397-2400, October 25, 2004.
Trifunovski, Alexandra CA; Josephson, Anna; Ringman, Andreas; Brene, Stefan; Spenger, Christian; Olson, Lars
Abstract:
Axonal regeneration after injury can be limited in the adult CNS by the presence of inhibitory proteins such as Nogo. Nogo binds to a receptor complex that consists of Nogo receptor (NgR), p75NTR, and Lingo-1. Nogo binding activates RhoA, which inhibits axonal outgrowth. Here we assessed Lingo-1 and NgR mRNA levels after delivery of BDNF into the rat hippocampal formation, Lingo-1 mRNA levels in rats subjected to kainic acid (KA) and running in running wheels. Lingo-1 mRNA was not changed by running. However, we found that Lingo-1 mRNA was strongly up-regulated while NgR mRNA was down-regulated in the dentate gyrus in both the BDNF and the KA experiments. Our data demonstrate inverse regulation of NgR and Lingo-1 in these situations, suggesting that Lingo-1 up-regulation is one characteristic of activity-induced neural plasticity responses.

(C) 2004 Lippincott Williams & Wilkins, Inc.