Having taken a number of 13-hour flights in the past year, I can comment on a bit on this!

The biggest problem with flying is that there is absolutely no room in "economy seating." You're literally up against the person next to you, and there's nothing to be done about it. If you have the financial ability, business or first class would be a better arrangement for someone with RSD.

Swelling is also an issue, especially on a long flight. I wear long soccer socks when I fly (ok, I wear them a lot of the time when I'm not flying) because they act as compression garments and keep some of the swelling down.

My biggest problem with flying is boredom. Bring a good book!

-Betsy