Junior Member
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Join Date: Nov 2006
Posts: 23
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Junior Member
Join Date: Nov 2006
Posts: 23
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Statins and Vitamin D
About this idea of a Vitamin D connection with statins, I believe that has been pretty well proven. What hasn't been proven is - exactly what the connection is. The paper below suggests that "statins activate vitamin D receptors." I think he's wrong; I think there's a better explanation than that.
The full text is available on line at The Lancet.
Are statins analogues of vitamin D?
The Lancet 2006; 368:83-86
DOI:10.1016/S0140-6736(06)68971-X
Are statins analogues of vitamin D?
David S GrimesMD
Summary
There are many reasons why the dietary-heart-cholesterol hypothesis should
be questioned, and why statins might be acting in some other way to reduce the risk of coronary heart disease. Here, I propose that rather than being cholesterol-lowering drugs per se, statins act as vitamin D analogues, and explain why. This proposition is based on published observations that the unexpected and unexplained clinical benefits produced by statins have also been shown to be properties of vitamin D. It seems likely that statins activate vitamin D receptors.
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