One has to titrate the dose up REALLY SLOWLY. If you don't, and MIRAPEX seems to be "no good for you", you might have better luck if you go real slow with it. I tried it and couldn't tolerate it no way, but when i went up with it slowly on my second attempt with it, it seemed to alleviate the symptoms of PD quite well. I found it "zombifying", no hint of "boneriferocitizing"