Hi,
When I was taken off of depakote I had to be admitted into the hospital and slowly go off the drug. Depakote is a very adictive drug and the Drs. wanted to monitor me while going off the drug and changing over to diamox. Later my epi wanted me to go on keppra but I told him no because it causes more moodiness and tempers for some people.
It took about 2-3 weeks for my body to get used to being off depakote and I had a lot of withdraw seizures which are no fun but it always happens each time I change AED's. Here's wishing your brother and you the best. May God Bless You Both!

Sue