Hi Zuchini
A more recent, 2007, paper on inflammation is
REVIEW
Inflammation as a causative factor in the aetiology
of Parkinson’s disease.
http://www.nature.com/bjp/journal/v1.../0707167a.html
British Journal of Pharmacology (2007) 150, 963–976
& 2007 Nature Publishing Group All rights reserved 0007–1188/07 $30.00
P.S. Whitton
Where dysfunction of the BBB pops up again. I now have a very large file of evidence including where PWP have all been shown to have defective BBB's.
A long list of nearly every beneficial compound or treatment reduces the porosity of the BBB, with curcumin (mentioned in your article) leading the way. A long list of substances or treatments which exacerbate our symptons, like stress, all open the BBB permeability.
When time factors are considered, it seems that the long term effect may be toxins entering the brain through the widened BBB, whilst short term effects could be loss of dopamine (which can't normally pass the BBB) itself, from the brain into the bloodstream. Another effect can be the widened BBB may now admit carbidopa to the brain, which will stop conversion of levodopa into dopamine.
I have the whole article, but it is huge, too big to enclose. If you want it, maybe I could send it you by e-mail?
Ron
page 970
"Previously, damage to the BBB has been demonstrated in
systemic infections as a result of the activation of various
mediators that cause multiple organ failure including the
brain (Herrera et al., 2005). Significantly, dysfunction of the
BBB has been shown in PD patients who had significantly
reduced function of the molecular pump p-glycoprotein
(Kortekaas et al., 2005). Additional evidence comes from the
systemic injection of LPS, which can cause a functional
breakdown of the BBB leading to granulocyte infiltration
into the mouse brain (Bohatschek et al., 2001), suggesting
that systemic infection and raised LPS can have an indirect
but profound effect on neurons in the CNS. Other external
factors such as infection, stroke and trauma may also disturb
the BBB, which can lead to the extravasation of substances
and the activation of microglia (Carvey et al., 2005;"