A few points to add but the starting article is great. And Ron, I would much like to have the article you mentioned.

First, the same inflammation that opens the BBB can at the same time open the similar barrier between the GI tract and the blood. This, particularly combined with constipation, dumps extra toxins into the system just as the BBB is impaired. Not good. Keep them innards moving.

Second, the LPS mentioned is the bacterial toxin I keep harping on and it is a product of most of the bacteria we encounter. When they die it is dumped into the system, so it is a constant presence with a fluctuating level. There are control systems that limit that level but they sometimes either fail or are overwhelmed
.
The interesting part is that LPS levels are such a good indicator of enemy bacteria populations that our immune system monitors it as an early warning system. LPS goes up, the alarm sounds. One of our problems seems to be that prenatal exposure to the same toxins can make us sensitized and the alarm goes off more often and we have more inflammation.