Originally Posted by glenntaj

--I agree with ConsiderThis' idea that you want to very carefully track your symptom exacerbations/remissions, to see just how closely related they might be with taking your supplements. It's a good idea to do this in diary form--memory can be unreliable.

Remember, too, that increased sensory symptoms may well be a good sign, as previously dormant nerves "wake-up" and try to reconnect to their targets; since they don't do this in the same pattern that was there originally, the process often is accompanied by a lot of weird symptoms that may appear to be "worsening", as the brain learns to reinterpret the signals/sensations. The real test is whether or not these sensations persist months to years. Neural "progress", given the slow rate of nerve regeneration/reconnection, is best measured over the long-term.

Regarding the taking of B12 at a different time from anything else--Brian's got the idea. The cobalamin molecule, in its various forms, is the largest molecule among any of the basic building-block nutrients or enzymes humans process, and therefore it is very easy to interfere with it's absorption (it's very easy to crowd it out). This is why it's recommended to take one's B12 seperately from anything else by at least an hour or so each way. I'm chewing on my lozenge right now, two hours post-breakfast and two hours (at least) before lunch.