please bear with me on this ,as I may be way off base. The reason for my alarm is that I was diagnosed diabetic March 1 and found myself attacked by toe to head neuropathy four days after I started Glucovance which is a Biguanide and is known to deplete b12. Every study I have seen suggests Hypoxsia as a contributing factor to DPN. So my logic ( I hope ) says that I could use all the red blood cells I can get a hold of. It may be screwy thinking though. It wouldn't be the first time for me! thanx..