Quote:
Originally Posted by flsun01
please bear with me on this ,as I may be way off base. The reason for my alarm is that I was diagnosed diabetic March 1 and found myself attacked by toe to head neuropathy four days after I started Glucovance which is a Biguanide and is known to deplete b12. Every study I have seen suggests Hypoxsia as a contributing factor to DPN. So my logic ( I hope ) says that I could use all the red blood cells I can get a hold of. It may be screwy thinking though. It wouldn't be the first time for me! thanx..
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4 days is not a realistic expectation for the effects of B12 lowering due to metformin (which is one ingredient in Glucovance--the other is glipizide).
Only about 30% experience B12 issues on metformin over time, and it has been shown that calcium supplements can help prevent this. It takes many months/years to manifest low B12 on the drug. If you are very low to begin with of course, that is different.
People however on the road to diabetes, can have PN before the diabetes is diagnosed. We have seen many posts here on this topic. So it just might be a coincidence of timing for your issues.
Anyone intolerant of sulfonamides cannot take glypizide safely. So if you think you are having allergic symptoms, you can ask your doctor to change you. If you are mild in presentation, metformin alone may be enough, for you.
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Weezie looking at petunias 8.25.2017
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