Hi bucky, I have been taking tramacet for about 1 year as well as arthotec and effexor, for the past 6 months I have noticed extremely large bruises all over my body, I talked with my dr as well as the pharmacist and they say different things. the dr says it might be the gluclosamine i take for my joints and the pharmacist says it might be the arthotec, which is a blood thinner, i have recently cut down on this but am still bruising alot.I have also heard that tramacet can cause liver damage which scares me .how will you know if this is true. If I dont take these pills I have alot aof pain , I have degenerative disc disease and pain in me legs when i walk so they take the edge of but the pain is always there. any wise words or suggestions. thanks Jacqueline