I had botox in my RSD leg a long time ago. I think it was either my sophomore or junior year of high school. They did it while I was under general anesthesia so I didn't feel anything. My foot was severely inverted and didn't get better on its own. The botox (and a tunneled epidural cath) seemed to work. It took lots of torturous PT, but it got better after that.

-Betsy