Hi Roz,

I absolutely agree.
I believe "something" is contributing to the continued irritation.
Perhaps it is the blood - brain barrier or just the blood - nerve interface & hence blood - brain.
I just "feel" that there is something causing perpetual irritation and to throw an idea out there - it may be any number of vectors transmitting a pathogen or an invasive protein (prion - like)....eg we don't have lymes here in Australia so perhaps there are other vectors.

This is where I am starting to concentrate my web investigations.

For now, and it could be a waste of time, but I am starting to look in the direction of parasites or other vectors that are known to carry these "protein enemies" that are common throughout the world.

There has to be a common thread and I am prepared to put in the time when I am able on the other hand I could be totally off the track.

I am beginning to wonder which gene or genes are switched on by the irritant to cause our pain pathways and what the irritant is.

I'll avoid diving in at the deep end with the direction so far but I don't think your far off the mark.

Hugs
Auberon