Thread: Pd Subtypes
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Old 09-27-2006, 06:47 PM
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Paula, regarding your comment about dementia, this article is interesting:

Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross-sectional comparative study

Movement Disorder
Volume 18, Issue 8, Pages 884-889
Published Online: 21 Mar 2003

http://www3.interscience.wiley.com/c...5647/HTMLSTART

"A significant negative correlation between bradykinesia and rigidity, parkinsonian features mediated by dopamine deficiency, and the severity of intellectual impairment has been reported.[8-10][13]

Tremor, on the other hand, may be of good prognostic significance in terms of incident dementia,[15] although this has not been a consistent observation.[12][44]

Others have suggested that motor features mediated by non-dopaminergic pathways, namely, problems with speech, posture, and balance, correlate more closely with incident dementia in PD than tremor, rigidity, and bradykinesia.[5][6][9][11]

Our results are consistent with these findings, in demonstrating an over-representation of the PIGD subtype in a group of patients with PDD, defined according to DSM-IV criteria plus visual hallucinations and/or fluctuating cognition, as well as extending this observation to DLB patients."
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