Thats a tough question, i think it would depend upon cause and how soon you are able to address it and could vary from person to person. IN my case i havent gotten any better as far as numbness and balance, if anything im more numb, but the areas involved have not spread in two years. Was that due to exercize, supplements, interferential therapy, tens, or just how the disease progressed i dont really know. I do know that the burning and throbbing pains have greatly lessened and it was as i was being treated by interferential therapy and taking B1.