It's probably best to go for the skin biopsy BEFORE the sural nerve biopsy. From my knowledge, the skin biopsy has no complications usually but the nerve biopsy leaves the area permanently numb/irritated. And yes, MANY people get spinal tap headaches and they usually last for a week. I hope your husband finds a cause so they can treat it right away. Have you guys tried natural medicine/alternative treatments? EG. Vitamins, the rebuilder, microvas, tens, anodyne and the like?