On all the opana, oxymorphone AND effexor i was totally on my butt yesterday!!! I can't keep that up, so I reduced the opana by 1/3 and I have only needed 1 breakthrough this afternoon after a lot of activity ( i had been averaging 3-5 a day). All in all it works out to something close to but maybe not quite half...mostly, I was really surprised by the amount of pain relief so quickly.
It should be OK, as I have been slowly reducing over the past two weeks..if anything feels funny I'll give the good Dr J a call. thanks for the concern