Ol'cs...just about 3 weeks ago, my pwp (Doreen) mentioned to me that for about two weeks, she had felt so well that she didn't even feel that she had PD. Then, suddenly...about 10 days ago...BOOM...she was sitting in a chair (we had visitors), and I suddenly noticed her shaking with that all-body dyskinesia that I have mentioned in some previous posts lately. She was SO dyskinetic that, without exaggeration, it reminded me of Michael J. Fox at his worst, i.e., when I've seen him in tv NOT having taken his PD medication(s) purposely to illustrate the severity of PD. Needless to say, I was shocked and extremely scared. In the 10 years plus that Doreen has had PD (tremor dominant) with only a very SLIGHT dyskinesia recently, I had never experienced this...and this was an all-body dyskinesia that lasted throughout the entire next day...and even now, that is the most dominant symptom...and, along with this, she now seems to have memory impairment...confusion...and, from what I have been able to determine, the medications that are part of her PD regimen (in addition to the Sinemet), i.e., Cogentin and Comtan, can definitely be a factor..with Comtan seemingly being responsible for aggravating PD symptoms...also listed as having dyskinesia as the first side effect in clinical studies...and, also stated in my reading: "Comtan may potentiate the dopaminergic side effect of levodopa and MAY CAUSE AND/OR EXACERBATE PREXISTING DYSKINESIAS. I view this as a very real possibility (probability) of this very sudden, full-blown "attack" of severe dyskinesia that occurred very recently..and this is certainly ONE topic that I will be discussing with Doreen's neurologist on Friday. I really only intended, here, Ol'cs to point out that...yes...one day, fine...the next, horrible...in sync with your message. I have been searching/researching all week long...including here on the forum...for information that will help me with the upcoming visit on Friday.
I am hoping...and praying...that all this is "med"-related and NOT progression that literally happened "overnight". Of course, now begins the adjustment of medication(s) period, but, I'll be "ok" with that rather than having to deal with the knowledge that it's progression. I'm sorry if I got too far off the track with your post, ol'cs...but, I just seemed to have to share this with you and everyone here.

Therese