Sleep. Without it I am almost guaranteed a bad day. I give in to taking meds to sleep but not every night if I can help it. .5 mg of lorazepam helps to calm me down and get at least 3 to 4 hours of sleep and then I am usually up again. My MDS prescribed a small amount of Seroquel which helped also but left me very groggy the next day. I will only use it when I am really feeling sleep deprived. Sometimes I just go with the flow and try not to think about it as a problem. It seems to be common for PWP so when you are up in the night you know you are not alone, a lot of us are going through the same thing.