Wow, that was a great article on homocysteine. I found out a few weeks ago my level was too high and was told by the hematologist to take a vitamin with folic acid, b12 and b6. I'm hoping this may be the solution to my problem with major depression for the past year or so. I was diagnosed with factor v leiden (blood clot gene) in August which was why I went to the hematologist in the 1st place. My fingernails, just as in Clare's picture have been bluish around the cuticle, my moons have disappeared. I have been cold to the point I had my heater on in my office while everyone had the air on. And sore tongue? My tongue would look as if it were peeling. And I would get bumps on it that hurt that I couldn't eat anything. And people (including my doctor) don't believe you when you tell them what is bothering you. I feel as if I have been dismissed so many times. Thank you for the article and hopefully with the vitamins I can finally get myself back in order.