Dear Ol'cs, Thanks for sharing your experience with sinemet. Your unreserved biography of sinemet really enlighten me of what to ask my neurologist in my next visit, which is scheduled to be on coming Saturday. Here's my story: In the first two years after dx, I only took 5mg selegiline per day and it kept me symptom free! On third year, I was put on requip but did not have "too good response" (neither did I have those adverse effects). On the forth year, I started sinemet cr 25/100 x 3 per day and it served me well. on the fifth year, I switched to stavelo 100 x 3 per day and until 8 months ago, neupro patch 6mg was added (dosing up from 2mg/ 4mg).

Dear Charlie, I always found your input to be very technical and inspiring, and will ask my neurologist to add one CR for a good sleep.

Good luck to all!

LING