Quote:
Originally Posted by glenntaj
--and he certainly has first hand experience in this realm.
There is increasing evidence that high insulin levels, especially as revealed during glucose challenge, may well be the first step on the path to diabetes, but that one can get neuropathic symptoms--especially small-fiber sensory ones--well before a frank diagnosis of diabetes can be made, when one is in the realm of "impaired glucose tolerance". And subtle abnormalities of glucose/insulin relationship may not be observable except through such extended glucose tolerance testing (in other words, your "fasting" glucsoe levels and hemoglobin A1c readings may be nicely in range, and you can still have a problem).
High insulin levels (that are not caused by insulinoma, which is very rare) are usually due to insulin resistance--the body's cells have become inured to its actions, meaning much more must be produced to get glucose into cells past resisting cell walls so as to keep blood glucose within tolerable levels. Without dietary and/or exercise intervention, resistance often will increase until the glucose levels can no longer be kept within non-diabetic ranges.
Here are some papers that talk about pre-diabetic neuropathy (so you can show the nuero):
http://www.massgeneral.org/neurology...dOaklander.pdf
http://appneurology.com/showArticle....leId=188500771
http://care.diabetesjournals.org/cgi...full/24/8/1448
http://www.neurology.org/cgi/content/abstract/57/9/1701
http://www.medpagetoday.com/Neurolog...rology/tb/3538 |
Brian,
Thanks for the help. The first three and last links there don't work. They have the three dots breaking them up.
I know pre-diabetes is linked to PN. That is why I asked my family doctor for the 3 hour glucose tolerance test. He said no but I insisted to have it. It did come back positive and then he diagnosed me as pre-diabetes.
Also I asked him about the abnormal ratio of the albumin and globulin in the blood test which tests for kidney malfunction. He ordered a urine analysis and then a 24 hour urine analysis. They came back high and he wrote me a prescription for a Nephrologist.
So for pre-diabetes I've been avoiding sugar and bread and having mostly fish and vegetables and exercising. I am normal body weight. I wonder what else would cause high insulin levels though besides insulin resistance. Also why do people with pre-diabetes get PN when people with long standing diabetes don't get it? Obviously I have high insulin production and also the beginning of PN.