Getting up in the night when no late time fluid intake is done, can reflect
peripheral edema during the day. It can also signal a urinary tract infection, or heavy consumption of vit C supplements which acidify the urine and make urgency occur.

As people age they tend to start to get up in the night. Once is considered
fairly typical.

If the heart cannot manage the fluid during the day, the kidneys clamp down and release when you lie down. So you have to get up in the night.

Hypertension, beginning congestive heart failure, hypothyroidism, all can lead to edema in the periphery.

So if your new supplement additions are improving your metabolism, and you see this improvement that is good news. The Betaine improves stomach acidity which improves protein digestion and other nutrient absorption. When the GI tract is impaired your whole body becomes impaired because of it.
Zinc, iron, calcium, folic acid, and B12 all need an acidic stomach to be absorbed properly.