But PN does cause problems with the blood supply to the extremities I believe. And is it possible that the knee is developing some arthritic tendencies? My stepmom fell on her knee and much later on (over a year) it started swelling. Finally the doctor MRI'd it and found that the knee injury had caused blood supply problems to the knee bones. The bones developed growth problems and the knee had to be replaced. Have they MRI'd the knee or xrayed it? Elevated C-Reactive protein is a marker for inflammation.

Not sure about the Vita. C level and I remember his iron problems. Good luck.
Billye