YOu said sinemet cr 25/100 ??? Sinemet cr is formulated as 50mg carbidopa to 200 mg of levodopa, that is 50/200, it is a peach colored tablet not a yellow colored one. I think that mom should take up one or two 25/100 sinemet regular release along with a 50/200 Controlled release sinemet every 8 to 12 hours, this giving her a total l-dopa intake of 800-1200mg /day. Start off with 800 mg/day total L-dopa as 1200mg may be too much rigth now. Maybe also include 100-200mg/day of amantadine, and some Klonopin for tremors 1-2 mg /day. I'll bet that she is undermedicated and doesn't have anything in her bloodstream as a dopa reserve. Just my opinion. cs