Thanks for your replies, long day, just got home. I forgot to put she is taking Two- 25/100 sinemet cr (mfg by Merk)every 3-4 hours, and her MDS said if she needs them in the night to take them. She has to take the brand name, and she did try regular sinemet, which caused nausea/vomiting resulting in her weight going from 143 in 2001 when she started regular sinemet (the neurologist also had her on comtan back then too) to 101 at her last MSD visit 3 weeks ago. She did try brand name sinemet again a few years ago in addition to the CR, but the nausea/vomiting started again.

The main concern now is the feeling that her throat is swollen, feeling of not being able to breathe, and the mucous. All of which go away when the sinemet cr eventually works. The Zelapar was just introduced 3 weeks ago to be taken in addition to the CR because the off times are lasting longer, I guess its really too soon to tell much about the Zelapar.
Thanks
Narda