mrsd, thank yo for this information. My PCP and I have been trying to understand why my B6 has been elevated.

I have discovered that even though my B12 is well within normal (last was over 700) I am functionally deficient in methyl-B12 as evidenced by lowering of my homocystiene levels to below high normal for the first time a week after starting sublingual methyl-B12 mega doses - this was a few weeks ago. I have developed a number of neurological symptoms, especially over the last year and a half that appeared to mimic MS. Many of those symptoms are improving now.

I guess its not such a far stretch of the imagination that my ability to covert B6 into P5P might be impaired as well.